Multi-Factor Experimental Designs for Exploring Response Surfaces

Experimental Optimization and Response Surfaces

Multi-factor designs. IV. How multi-factor designs improve the estimate of total error by accounting for protocol-specific biases.

Total error is often calculated as a combination of random error and fixed bias. However, the specific protocols used to estimate random error and fixed bias are themselves variable factors that can affect the estimate of total error. We refer to biases such as assay drift, sample-to-sample carryover, and reagent carryover as examples of fixed biases that are protocol-specific and distinguish t...

Multi-objective optimal experimental designs for event-related fMRI studies

In this article, we propose an efficient approach to find optimal experimental designs for event-related functional magnetic resonance imaging (ER-fMRI). We consider multiple objectives, including estimating the hemodynamic response function (HRF), detecting activation, circumventing psychological confounds and fulfilling customized requirements. Taking into account these goals, we formulate a ...

Experimental Designs for Efficient Free - Space Multi - Spatial - Mode Optical

In optical communications, two measures of efficiency are commonly at odds. The first is the photon information efficiency (in bits/photon) which measures the information that each detected photon conveys; the second is the spectral efficiency (in bits/s/Hz) which measures the bit rate achieved under limited bandwidth. One interesting communication protocol which can simultaneously obtain high ...

Response Surface Experimental Designs for Investigating Interspecific Competition

Competition is an important interaction in ecology, and many experiments have been done to examine the effects of intraspecific and interspecific competition. Unfortunately, most of these experiments have been done using either substitution or additive experimental designs. Substitution designs, and to a lesser extent additive designs, severely limit the useful inferences that ecologists can dr...